Detection of the Urinary Biomarkers PYD, CTX-II, and DPD in Patients with Kashin-Beck Disease in the Qinghai Province of China.

Zhi Jun Zhao; Guang Lan PU; Pei Zhen Zhan; Qiang LI; Chun Ning WU; Li Hua Wang

Return

Detection of the Urinary Biomarkers PYD, CTX-II, and DPD in Patients with Kashin-Beck Disease in the Qinghai Province of China.

Author: Zhi Jun ZHAO ¹ ; Guang Lan PU ¹ ; Pei Zhen ZHAN ¹ ; Qiang LI ¹ ; Chun Ning WU ¹ ; Li Hua WANG ²
Author Information

1. Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, Qinghai, China.
2. Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150087, Heilongjiang, China.
Publication Type:Letter
MeSH: Adult; Amino Acids; urine; Biomarkers; urine; China; Collagen Type II; urine; Female; Humans; Kashin-Beck Disease; diagnosis; urine; Male; Middle Aged; Peptide Fragments; urine
From: Biomedical and Environmental Sciences 2017;30(5):380-383
CountryChina
Language:English
Abstract: Kashin-Beck disease (KBD) is an endemic degenerative osteoarthropathy of uncertain etiology. The aim of our study was to identify changes in C-telopeptide of type II collagen (CTX-II), pyridinoline (PYD), and deoxypyridinoline (DPD) among KBD patients. 54 KBD patients and 78 healthy controls were included this study. Urinary samples were collected and measured by ELISA. The median quantities of PYD, CTX-II, and DPD of KBD patients were 1107.73 ng/μmol.cre, 695.11 ng/μmol.cre, and 1342.34 pml/μmol.cre, while the median quantities of healthy controls were 805.59 ng/μmol.cre, 546.47 ng/μmol.cre, and 718.15 pml/μmol.cre, respectively. The differences between KBD patients and healthy controls were statistically significant (Z = 4.405, 3.653, and 3.724; P < 0.001). The higher levels of PYD, CTX-II, and DPD detected in KBD patients indicate that they could be used as biomarkers of KBD.