Role of Immune Microenvironmental Factors for Improving the IPI-related Risk Stratification of Aggressive B Cell Lymphoma.
- Author:
Yi GONG
1
,
2
;
Rui CHEN
3
;
Xi ZHANG
4
;
Zhong Min ZOU
5
;
Xing Hua CHEN
4
Author Information
- Publication Type:Journal Article
- Keywords: Aggressive B cell lymphoma; IPI; PD-1; PD-L1; Risk stratification; Tumor microenvironment; Tumor-infiltrating lymphocytes
- MeSH: Adult; Biomarkers, Tumor; Gene Expression Regulation, Neoplastic; immunology; Humans; Lymphoma, B-Cell; classification; pathology; Prognosis; Retrospective Studies; Survival Analysis
- From: Biomedical and Environmental Sciences 2017;30(7):492-500
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the risk stratification of aggressive B cell lymphoma using the immune microenvironment and clinical factors.
METHODSA total of 127 patients with aggressive B cell lymphoma between 2014 and 2015 were enrolled in this study. CD4, Foxp3, CD8, CD68, CD163, PD-1, and PD-L1 expression levels were evaluated in paraffin-embedded lymphoma tissues to identify their roles in the risk stratification. Eleven factors were identified for further evaluation using analysis of variance, chi-square, and multinomial logistic regression analysis.
RESULTSSignificant differences in 11 factors (age, Ann Arbor stage, B symptom, ECOG performance status, infiltrating CD8+ T cells, PD-L1 expression, absolute blood monocyte count, serum lactate dehydrogenase, serum iron, serum albumin, and serum β2-microglobulin) were observed among patient groups stratified by at least two risk stratification methods [International Prognostic Index (IPI), revised IPI, and NCCN-IPI models] (P < 0.05). Concordance rates were high (81.4%-100.0%) when these factors were used for the risk stratification. No difference in the risk stratification results was observed with or without the Ann Arbor stage data.
CONCLUSIONWe developed a convenient and inexpensive tool for use in risk stratification of aggressive B cell lymphomas, although further studies on the role of immune microenvironmental factors are needed.