Serum Thyroglobulin-A Sensitive Biomarker of Iodine Nutrition Status and Affected by Thyroid Abnormalities and Disease in Adult Populations.

Yang DU; Yan Hui Gao; Zhuo Ying Feng; Fan Gang Meng; Li Jun Fan; Dian Jun Sun

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Serum Thyroglobulin-A Sensitive Biomarker of Iodine Nutrition Status and Affected by Thyroid Abnormalities and Disease in Adult Populations.

Author: Yang DU ^{1
,

2} ; Yan Hui GAO ¹ ; Zhuo Ying FENG ³ ; Fan Gang MENG ¹ ; Li Jun FAN ¹ ; Dian Jun SUN ¹ ;
Author Information

1. Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University
2. Key Lab of Etiology and Epidemiology, National Health and Family Planning Commission (23618504), Harbin 150086, Heilongjiang, China.
3. Heilongjiang Land Reclamation Bureau General Hospital, Harbin 150088, Heilongjiang, China.
Publication Type:Journal Article
Keywords: High iodine; Iodine deficiency; Thyroglobulin
MeSH: Adult; Biomarkers; blood; China; Cross-Sectional Studies; Female; Humans; Iodine; Male; Middle Aged; Thyroglobulin; blood; Thyroid Diseases; blood; Thyroid Gland; metabolism
From: Biomedical and Environmental Sciences 2017;30(7):508-516
CountryChina
Language:English
Abstract:
OBJECTIVETo evaluate the usefulness of the thyroglobulin (Tg) level in adults as a nutritional biomarker of iodine status and to identify the factors related to the serum Tg level.
METHODSA cross-sectional study was conducted in adult populations of areas differing in iodine nutrition from three provinces (Autonomous Region) in China. Serum levels of thyroid hormones and Tg as well as thyroid autoantibodies were measured. The thyroid volume and nodule were measured by ultrasound. A multivariate linear regression analysis was used to assess iodine intake and other indeterminate factors associated with the serum Tg level.
RESULTSA total of 573 adults were recruited for this study. The serum Tg levels differed significantly among the three groups (22.27 μg/L, 9.73 μg/L and 15.77 μg/L in the excess, more-than-adequate, and deficient groups, respectively). The results of multivariate linear regression analysis indicate that excess and deficient iodine intake, goiter, thyroid nodule, hypothyroidism are significantly related with higher Tg level, and TgAb positivity is significantly related with lower serum Tg.
CONCLUSIONThe serum Tg level reflects abnormal thyroid function and is a sensitive functional biomarker of iodine nutrition status.