Grape Seed Procyanidin Extract Reduces Arsenic-Induced Renal Inflammatory Injury in Male Mice.
- Author:
Cheng WANG
1
;
Jun LI
2
;
Guan Ling SONG
1
;
Qiang NIU
1
;
Shang Zhi XU
1
;
Gang Ling FENG
1
;
Hai Xia WANG
1
;
Yu LI
1
;
Shu Gang LI
1
;
Feng LI
3
;
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arsenic; toxicity; Grape Seed Extract; therapeutic use; Inflammation; chemically induced; drug therapy; Kidney Diseases; chemically induced; drug therapy; Male; Mice; Proanthocyanidins; therapeutic use
- From: Biomedical and Environmental Sciences 2017;30(7):535-539
- CountryChina
- Language:English
- Abstract: The aim of the present study is to evaluate the ability and mechanism by which grape seed procyanidin extract (GSPE) relieves arsenic trioxide (As2O3)-induced renal inflammatory injury. Therefore, male Kunming mice were treated with As2O3 and/or GSPE by gavage for 5 weeks. Mice were then sacrificed and inflammatory cytokines of kidneys were examined by ELISA, whereas the expression levels of molecules involved in the nuclear factor (NF)-κB signaling pathway were evaluated by both qRT-PCR and Western blot. Our results indicate that GSPE prevents As2O3-mediated renal inflammatory injury by inhibiting activation of the NF-κB signaling pathway and inflammatory cytokine production, while promoting expression of anti-inflammatory cytokines.
