Bitter Melon Powder Protects against Obesity-associated Fatty Liver Disease by Improving Colonic Microenvironment in Rats with High-fat Diet-induced Obesity.
- Author:
Juan BAI
1
;
Ying ZHU
1
;
Ying DONG
1
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Colon; drug effects; Dietary Fats; administration & dosage; adverse effects; Fatty Liver; etiology; prevention & control; Feces; chemistry; HT29 Cells; Humans; Momordica charantia; Obesity; complications; Powders; Rats
- From: Biomedical and Environmental Sciences 2017;30(8):611-615
- CountryChina
- Language:English
- Abstract: This study explored how bitter melon powder (BMP) alters the colonic microenvironment during the development of obesity-associated fatty liver in rats. We observed that BMP effectively inhibited the body weight gain and lipid accumulation in the liver, ameliorated glucose intolerance, and increased the colon weight after an 8-week treatment compared to that in the high-fat diet (HFD) group. BMP significantly decreased fecal water toxicity towards HT-29 cells, as revealed by the cell counting kit (CCK)-8 assay results, and the mRNA expression of Toll-like receptor 4 (TLR4) in colon mucosa. Additionally, gut permeability in the BMP group was restored to normal levels. Finally, BMP alleviated the inflammatory state of the rat colon mucosa and liver tissues as well as the systemic inflammation.
