Combined Effects of Family History of Cardiovascular Disease and Serum C-reactive Protein Level on the Risk of Stroke: A 9.2-year Prospective Study among Mongolians in China.

Zheng Bao Zhu; Xin Feng Huangfu; Chong Ke Zhong; Yi Peng Zhou; Yun Fan Tian; Batu Buren; Tian XU; Ai Li Wang; Hong Mei LI; Ming Zhi Zhang; Yong Hong Zhang

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Combined Effects of Family History of Cardiovascular Disease and Serum C-reactive Protein Level on the Risk of Stroke: A 9.2-year Prospective Study among Mongolians in China.

Author: Zheng Bao ZHU ¹ ; Xin Feng HUANGFU ¹ ; Chong Ke ZHONG ¹ ; Yi Peng ZHOU ¹ ; Yun Fan TIAN ¹ ; Batu BUREN ² ; Tian XU ³ ; Ai Li WANG ¹ ; Hong Mei LI ¹ ; Ming Zhi ZHANG ¹ ; Yong Hong ZHANG ¹
Author Information

1. Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
2. Department of Epidemiology, Tongliao Center for Disease Prevention and Control, Tongliao 028005, Inner Mongolia, China.
3. Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China
Publication Type:Journal Article
Keywords: C-reactive protein; Family history of cardiovascular disease; Prospective study; Stroke
MeSH: Asian Continental Ancestry Group; C-Reactive Protein; metabolism; Cardiovascular Diseases; epidemiology; genetics; China; Genetic Predisposition to Disease; Humans; Prospective Studies; Risk Factors; Stroke; epidemiology
From: Biomedical and Environmental Sciences 2017;30(9):632-640
CountryChina
Language:English
Abstract:
OBJECTIVEWe aimed to evaluate the combined effect of a family history of cardiovascular disease (CVD) and high serum C-reactive protein (CRP) on the stroke incidence in an Inner Mongolian population in China.
METHODSA prospective cohort study was conducted from June 2002 to July 2012, with 2,544 participants aged 20 years and over from Inner Mongolia, China. We categorized participants into four groups based on the family history of CVD and CRP levels.
RESULTSWe adjusted for age; sex; smoking; drinking; hypertension; body mass index; waist circumference; and blood glucose, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels. Compared with the group with no family history of CVD/low CRP levels, the group with family history of CVD/high CRP levels had a hazard ratio (HR) of 1.78 [95% confidence interval (CI), 1.03-3.07; P = 0.039] of stroke, and an HR of 2.14 (95% CI, 1.09-4.20; P = 0.027) of ischemic stroke. The HRs of hemorrhagic stroke for the other three groups were not statistically significant (all P > 0.05).
CONCLUSIONParticipants with both a family history of CVD and high CRP levels had the highest stroke incidence, suggesting that high CRP levels may increase stroke risk, especially of ischemic stroke, among individuals with a family history of CVD.