DNA Methylation and Birth Weight: a Genome-wide Analysis.
- Author:
Li Li MAO
1
,
2
;
Xin Hua XIAO
3
;
Qian ZHANG
3
;
Jia ZHENG
3
;
Wen Hui LI
3
;
Miao YU
3
;
Hua Bing ZHANG
3
;
Fan PING
3
;
Jian Ping XU
3
;
Xiao Jing WANG
3
Author Information
- Publication Type:Journal Article
- MeSH: Birth Weight; DNA Methylation; Female; Gene Expression Regulation, Developmental; physiology; Genome-Wide Association Study; Humans; Infant, Newborn; Male; Organ Size; Placenta; anatomy & histology; Pregnancy; Signal Transduction
- From: Biomedical and Environmental Sciences 2017;30(9):667-670
- CountryChina
- Language:English
- Abstract: The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite-converted DNA. We have identified many differentially methylated CpG sites in experimental groups; these sites involved in hundreds of signalings. Among these, more than ten pathways were referred to the glucose and lipid metabolism. Methylation changes in the insulin-signaling pathway (ISP), adipocytokine signaling pathway (ASP) and MAPK signaling pathway are involved in the fetal programming of diabetes..
