Role of Diabetes Mellitus on Treatment Effects in Drug-susceptible Initial Pulmonary Tuberculosis Patients in China.

Yan MA; Mai Ling Huang; Tao LI; Jian DU; Wei Shu; Shi Heng Xie; Hong Hong Wang; Guo Feng Zhu; Shou Yong Tan; Yan Yong FU; Li Ping MA; Lian Ying Zhang; Fei Ying Liu; Dai Yu HU; Yan Ling Zhang; Xiang Qun LI; Yu Hong Liu; Liang LI

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Role of Diabetes Mellitus on Treatment Effects in Drug-susceptible Initial Pulmonary Tuberculosis Patients in China.

Author: Yan MA ^{1
,

2
,

3} ; Mai Ling HUANG ¹ ; Tao LI ⁴ ; Jian DU ¹ ; Wei SHU ¹ ; Shi Heng XIE ¹ ; Hong Hong WANG ¹ ; Guo Feng ZHU ⁵ ; Shou Yong TAN ⁶ ; Yan Yong FU ⁷ ; Li Ping MA ⁸ ; Lian Ying ZHANG ⁹ ; Fei Ying LIU ¹⁰ ; Dai Yu HU ¹¹ ; Yan Ling ZHANG ¹² ; Xiang Qun LI ⁵ ; Yu Hong LIU ¹ ; Liang LI ¹ ;
Author Information

1. Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
2. Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
3. Administration Office, Clinical Center on Tuberculosis Control, Chinese Center for Disease Control and Prevention, Beijing 101149, China.
4. .
5. Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
6. Guangzhou Chest Hospital, Guangzhou 510095, Guangdong, China.
7. Tianjin Centers for Disease Control and Prevention, Tianjin 300041, China.
8. Department of TB Control, Henan Center for Disease Control and Prevention, Zhengzhou 450016, Henan, China.
9. Hebei Center for Disease Control and Prevention, Shijiazhuang 050021, Hebei, China.
10. Department of TB Control, Guangxi Center for Disease Control and Prevention, Nanning 530021, Guangxi, China.
11. Chongqing Anti-tuberculosis Institute, Chongqing 400050, China.
12. Yunnan Center for Disease Control and Prevention, Kunming 650022, Yunnan, China.
Publication Type:Journal Article
Keywords: Diabetes mellitus; Treatment outcome; Tuberculosis
MeSH: Antitubercular Agents; therapeutic use; China; epidemiology; Diabetes Mellitus; epidemiology; therapy; Female; Humans; Male; Mycobacterium tuberculosis; drug effects; Tuberculosis, Pulmonary; complications; drug therapy; epidemiology; microbiology
From: Biomedical and Environmental Sciences 2017;30(9):671-675
CountryChina
Language:English
Abstract: We assessed the role of diabetes mellitus (DM) on treatment effects in drug-susceptible initial pulmonary tuberculosis (PTB) patients. A prospective study was conducted in eight provinces of China from October 2008 to December 2010. We enrolled 1,313 confirmed drug-susceptible initial PTB patients, and all subjects received the treatment regimen (2H3R3E3Z3/4H3R3) as recommended by the national guidelines. Of the 1,313 PTB patients, 157 (11.9%) had DM; these patients had more sputum smear-positive rates at the end of the second month [adjusted odds ratios (aOR) 2.829, 95% confidence intervals (CI) 1.783-4.490], and higher treatment failure (aOR 2.120, 95% CI 1.565-3.477) and death rates (aOR 1.536, 95% CI 1.011-2.628). DM was a contributing factor for culture-positive rates at the end of the second month and treatment failure and death of PTB patients, thus playing an unfavorable role in treatment effects of PTB.