- Author:
Xue Lian LI
1
,
2
,
3
;
Na XIE
1
;
Song Wang WANG
4
;
Qian Hong WU
5
;
Yan MA
1
;
Wei SHU
1
;
Hong Mei CHEN
1
;
Li Qun ZHANG
1
;
Xiao Guang WU
1
;
Li Ping MA
1
;
Nan Ying CHE
1
;
Meng Qiu GAO
1
;
Author Information
- Publication Type:Journal Article
- Keywords: Cerebrospinal fluid; Diagnosis; T-SPOT.TB; Tuberculous meningitis
- MeSH: China; epidemiology; Humans; Sensitivity and Specificity; Tuberculosis, Meningeal; cerebrospinal fluid; diagnosis; epidemiology
- From: Biomedical and Environmental Sciences 2017;30(9):681-684
- CountryChina
- Language:English
- Abstract: The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid (CSF) T-SPOT.TB test for the diagnosis of TB meningitis (TBM). A retrospective analysis of 96 patients with manifested meningitis was conducted; T-SPOT.TB test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). A receiver operating characteristic (ROC) curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T-SPOT.TB test were 97.8%, 78.0%, 80.3%, and 97.5%, respectively, for 52 patients (54.2%) of the 96 enrolled patients. The area under the curve (AUC) was 0.910, and the sensitivities of CSF T-SPOT.TB for patients with stages I, II, and III of TBM were 96.7%, 97.2%, and 98.9%, respectively. CSF T-SPOT.TB test is a rapid and accurate diagnostic method with higher sensitivity and specificity for diagnosing TBM.