A Genetic Susceptibility Study of Lung Cancer Risk Potentially Associated with Polycyclic Aromatic Hydrocarbon Inhalation Exposure.

Nan Lin; Xin Lin MU; Gui Lian Wang; Yu Ang Ren; De Liang Tang; Bin Wang; Zhi Wen LI; Shu SU; Hai Dong Kan; Shu Tao

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A Genetic Susceptibility Study of Lung Cancer Risk Potentially Associated with Polycyclic Aromatic Hydrocarbon Inhalation Exposure.

Author: Nan LIN ¹ ; Xin Lin MU ² ; Gui Lian WANG ³ ; Yu Ang REN ¹ ; De Liang TANG ⁴ ; Bin WANG ⁵ ; Zhi Wen LI ⁵ ; Shu SU ¹ ; Hai Dong KAN ⁶ ; Shu TAO ¹
Author Information

1. Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China.
2. Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China.
3. Intensive Care Unit, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100026, China.
4. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States of America.
5. Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, China.
6. School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China.
Publication Type:Journal Article
MeSH: Adenocarcinoma; chemically induced; epidemiology; genetics; Air Pollutants; toxicity; China; Genetic Predisposition to Disease; Humans; Inhalation Exposure; Lung Neoplasms; chemically induced; epidemiology; genetics; Polycyclic Aromatic Hydrocarbons; toxicity
From: Biomedical and Environmental Sciences 2017;30(10):772-776
CountryChina
Language:English
Abstract: To establish a genetic susceptibility assessment model of lung cancer risk potentially associated with polycyclic aromatic hydrocarbon (PAH) inhalation exposure among non-smokers in China, a total of 143 patients with lung adenocarcinoma and 143 cancer-free individuals were recruited. Sixty-eight genetic polymorphisms in 10 pathways related to PAH metabolism and tumorigenesis were selected and examined. It was observed that 3 genetic polymorphisms, along with 10 additional genetic polymorphisms via gene-gene interactions, significantly influenced lung cancer risk potentially associated with PAH inhalation exposure. Most polymorphisms were associated with PAH metabolism. According to the established genetic susceptibility score (GSS), lung cancer risk increased with a rise in the GSS level, thereby indicating a positive dose-response relationship.