Identification and Validation of Candidate Radiation-responsive Genes for Human Biodosimetr.

Shuang LI; Xue LU; Jiang Bin Feng; Mei Tian; Qing Jie Liu

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Identification and Validation of Candidate Radiation-responsive Genes for Human Biodosimetr.

Author: Shuang LI ¹ ; Xue LU ¹ ; Jiang Bin FENG ¹ ; Mei TIAN ¹ ; Qing Jie LIU ¹
Author Information

1. China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China.
Publication Type:Journal Article
Keywords: Bibliometric; Biodosimetry; Dose estimation; Gene expression; Ionizing radiation
MeSH: Dose-Response Relationship, Radiation; Gene Expression Profiling; Gene Expression Regulation; radiation effects; Humans; Radiometry; methods; Reproducibility of Results; Up-Regulation; radiation effects
From: Biomedical and Environmental Sciences 2017;30(11):834-840
CountryChina
Language:English
Abstract: The aim of the present study is to analyze the global research trend of radiation-responsive genes and identify the highly reproducible radiation-responsive genes. Bibliometric methods were applied to analyze the global research trend of radiation-responsive genes. We found 79 publications on radiation-responsive genes from 2000 to 2017. A total of 35 highly reproducible radiation-responsive genes were identified. Most genes are involved in response to DNA damage, cell proliferation, cell cycle regulation, and DNA repair. The p53 signal pathway was the top enriched pathway. The expression levels of 18 genes in human B lymphoblastoid cell line (AHH-1) cells were significantly up-regulated in a dose-dependent manner at 24 h after exposure to 0-5 Gy 60Co γ-ray irradiation. Our results indicate that developing a gene expression panel with the 35 high reproducibility radiation-responsive genes may be necessary for qualitative and quantitative assessment after exposure.