Comparison of T-2 Toxin and HT-2 Toxin Distributed in the Skeletal System with That in Other Tissues of Rats by Acute Toxicity Test.
- Author:
Fang Fang YU
1
;
Xia Lu LIN
1
;
Lei YANG
1
;
Huan LIU
1
;
Xi WANG
1
;
Hua FANG
1
;
ZMikko J LAMMI
2
;
Xiong GUO
1
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone and Bones; chemistry; metabolism; Rats; Rats, Sprague-Dawley; T-2 Toxin; analogs & derivatives; pharmacokinetics; toxicity; Tissue Distribution; Toxicity Tests, Acute
- From: Biomedical and Environmental Sciences 2017;30(11):851-854
- CountryChina
- Language:English
- Abstract: Twelve healthy rats were divided into the T-2 toxin group receiving gavage of 1 mg/kg T-2 toxin and the control group receiving gavage of normal saline. Total relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system (thighbone, knee joints, and costal cartilage) were significantly higher than those in the heart, liver, and kidneys (P < 0.05). The relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system (thighbone and costal cartilage) were also significantly higher than those in the heart, liver, and kidneys. The rats administered T-2 toxin showed rapid metabolism compared with that in rats administered HT-2 toxin, and the metabolic conversion rates in the different tissues were 68.20%-90.70%.
