Characteristics of Long-term Nonprogressors and Viremia Controllers Infected with HIV-1 via Contaminated Blood Donations or Transfusions Conducted 20 Years Earlier.
- Author:
Jia LIU
1
;
Pan Ying FAN
1
;
Xiu Juan XUE
1
;
Jiang Zhou YAN
1
;
Guo Qing SUN
1
;
Chun Hua LIU
1
;
Sui An TIAN
1
;
Ning LI
1
;
Ding Yong SUN
1
;
Qian ZHU
1
;
Zhe WANG
1
Author Information
- Publication Type:Journal Article
- From: Biomedical and Environmental Sciences 2017;30(12):907-912
- CountryChina
- Language:English
- Abstract: To characterize long-term nonprogressors (LTNPs) and viremia controllers (VCs), infected with HIV-1 through contaminated blood donation or transfusion between 1992 and 1996 in Henan, China. LTNPs and VCs were defined by CD4+T lymphocyte (CD4) count and viral load (VL). Of 29,294 patients infected with HIV-1 via contaminated blood donation or transfusion that had conducted for more than 20 years, 92 were LTNPs/VCs. There were 70 LTNPs (0.24%), 43 VCs (0.15%), and 48 LTNPs+VCs- (0.16%). VCs had a significantly lower CD4 nadir, compared to LTNPs and LTNPs+VCs-, and no significant differences for the highest VL and HIV-1 DNA. Cases P4 and P5 were LTNPs, while their VL reached approximately 4.3 log copies/mL. P6 was a VC, but with CD4 < 500 cells/μL constantly. Data from the LTNPs/VCs cohort provided valuable information, future research is needed.
