Effects of Maternal Marginal Iodine Deficiency on Interactions between Cerebellar Bergmann Glia Cells and Purkinje Cells in Rat Offspring.

Author: Ye YU ¹ ; Jing DONG ¹ ; Yuan WANG ¹ ; Yi WANG ¹ ; Hui MIN ¹ ; Zhong Yan SHAN ² ; Wei Ping TENG ² ; Jie CHEN ¹
Author Information

1. Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110112, Liaoning, China.
2. Department of Endocrinology and Metabolism, Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang 110001, Liaoning, China.
Publication Type:Journal Article
From: Biomedical and Environmental Sciences 2017;30(12):932-937
CountryChina
Language:English
Abstract: Iodine deficiency (ID) during early pregnancy has an adverse effect on children's psychomotor and motor function but the mechanism has not been clarified. Therefore, our aim was to study the effect of maternal marginal ID on cerebellar neurodevelopment and the underlying mechanism. After obtaining marginal ID rats, we examined interactions between Bergmann glia cells (BGs) and Purkinje cells (PCs) using immunofluorescence and expression of the glutamate transporter and receptor by western blot. Our results showed that marginal ID reduced the number of contacted points between BGs and PCs, and disturbed expression of the glutamate transporter and receptor. Our results support the hypothesis that marginal ID inhibits interactions of BGs-PCs, which may be involved in abnormal regulation of the glutamate transporter and receptor.