Intestinal Microbial Community Differs between Acute Pancreatitis Patients and Healthy Volunteers.

Xi Mei Zhang; Zheng Yu Zhang; Chen Huan Zhang; Jing WU; You Xin Wang; Guo Xin Zhang

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Intestinal Microbial Community Differs between Acute Pancreatitis Patients and Healthy Volunteers.

Author: Xi Mei ZHANG ¹ ; Zheng Yu ZHANG ¹ ; Chen Huan ZHANG ² ; Jing WU ³ ; You Xin WANG ⁴ ; Guo Xin ZHANG ⁵
Author Information

1. Department of Gastroenterology，Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu, China.
2. School of Public Health，Medical College of Soochow University, Suzhou 215000, Jiangsu, China.
3. Ruike-donghua Translational Medicine Research Center Co., Beijing 100176, China.
4. Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China.
5. Department of Gastroenterology, The First Affliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China.
Publication Type:Journal Article
From: Biomedical and Environmental Sciences 2018;31(1):81-86
CountryChina
Language:English
Abstract: A case control study including 45 acute pancreatitis and 44 healthy volunteers was performed to investigate the association between intestinal microbial community and acute pancreatitis. High-throughput 16S rRNA gene amplicon sequencing was used to profile the microbiological composition of the samples. In total, 27 microbial phyla were detected and the samples of pancreatitis patients contained fewer phyla. Samples from acute pancreatitis patients contained more Bacteroidetes and Proteobacteria and fewer Firmicutes and Actinobacteria than those from healthy volunteers. PCoA analyses distinguished the fecal microbial communities of acute pancreatitis patients from those of healthy volunteers. The intestinal microbes of acute pancreatitis patients are different from those of healthy volunteers. Modulation of the intestinal microbiome may serve as an alternative strategy for treating acute pancreatitis.