The role of cell adhesion, multidrug resistance and cell proliferation in short-term recurrent cases with T1G3 superficial bladder cancer.
- Author:
Yu-yan ZHU
1
;
Chui-ze KONG
;
Yu ZENG
;
Guo-you PANG
;
Chun-ming YANG
;
Zhi-xi SUN
Author Information
- Publication Type:Journal Article
- MeSH: ATP-Binding Cassette, Sub-Family B, Member 1; analysis; Adult; Cadherins; analysis; Cell Adhesion; Cell Division; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Ki-67 Antigen; analysis; Male; Neoplasm Recurrence, Local; etiology; Urinary Bladder Neoplasms; drug therapy; etiology; pathology
- From: Chinese Journal of Surgery 2003;41(12):893-896
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the roles of cell adhesion, multidrug resistance and cell proliferation in short-term recurrent cases with superficial bladder cancer, and the prognostic value of the three indexes.
METHODSImmunohistochemical staining for E-cad, P-gp and Ki-67 was performed on the tumors of 100 patients with stage T0-T1 transitional cell carcinoma of the bladder who had been included in a retrospective research by follow-up.
RESULTSE-cad and P-gp expression was positive in 51 (43.2%)and 17 (14.4%) of the tumors, respectively and mean proliferation index (PI) was 22.1%. The decrease in E-cad expression was accompanied with the increasing recurrent episodes (P < 0.05), while increase of P-gp expression and PI were accompanied with the increasing recurrence episodes (P < 0.05). There was significant difference according to E-cad, P-gp positivity and between T(1)G(3) patients and no-T(1)G(3) patients (P < 0.05). There was negative correlation of E-cad expression with P-gp expression and PI.
CONCLUSIONSMinimum adhesion, strong drug resistance and maximum proliferation are the main factors that promote short-term recurrence of superficial bladder cancer and also the inherent reasons for easy recurrence and high malignancy of T(1)G(3) tumors. During this course, the three aspects may interact.
