An experimental study on high intensity focused ultrasound combined with mitomycin treatment of bladder tumor.
- Author:
Guo-min WANG
1
;
Yuan-feng YANG
;
Li-an SUN
;
Zhi-bing XU
;
Ye-qing XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; Combined Modality Therapy; Female; Male; Mice; Mitomycin; therapeutic use; Ultrasonic Therapy; Urinary Bladder Neoplasms; pathology; therapy
- From: Chinese Journal of Surgery 2003;41(12):897-900
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the therapeutic effect and synergistic inhibition effect of high intensity focused ultrasound in combination with mitomycin on T739 mice bladder tumor.
METHODSBTT739 tumor-bearing mice receiving HIFU and/or mitomycin in two weeks, were divided into control group, low dose chemotherapy group, high dose chemotherapy group, HIFU group and HIFU combined chemotherapy group. The growth of mice tumor volume was observed in two weeks, by which we counted tumor volume doubling time and performed the growth curve. All specimens were analysed histologically.
RESULTSHIFU combined mitomycin has significant synergistic inhibition effect. Tumor tissue damage such as huge coagulation necrosis was observed using light microscopy. However, there were still some remaining alive cells. The apoptosis of tumor cell in HIFU group and HIFU combined chemotherapy group obviously increased in comparison with other groups.
CONCLUSIONSHIFU group, HIFU combined chemotherapy group can distinctively inhibit tumor growth; HIFU combined with mitomycin has notable synergistic inhibitory effect. HIFU may induce the apoptosis of tumor cell.
