A study of correlation between early postoperative relapse with lymph node micrometastasis in patients with N0 esophageal cancer.
- Author:
Zhou WANG
1
;
Xiang-yan LIU
;
Fan-ying LIU
;
Jing-han CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Esophageal Neoplasms; surgery; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Lymph Nodes; pathology; Lymphatic Metastasis; genetics; Male; Middle Aged; Mucin-1; genetics; Neoplasm Staging; Postoperative Period; RNA, Messenger; genetics; metabolism; Recurrence; Reverse Transcriptase Polymerase Chain Reaction
- From: Chinese Journal of Surgery 2004;42(2):68-71
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation between early postoperative tumor relapse with lymph node micrometastasis in the patients with pN(0) esophageal cancer.
METHODSUsing reverse transcriptase-polymerase chain reaction (RT-PCR), one hundred and sixty-six regional lymph nodes obtained from forty-three patients with esophagus cancer without invasion of the tumor confirmed by histopathologic analysis (pN(0)) were studied for further detecting mRNA of Mucin1 (MUC1) gene and determining nodal micrometastasis. All the patients underwent radical resection and regional lymph node dissection. Patients were followed up for one year to detect early tumor relapse. Difference in relapse was compared by chi(2) test.
RESULTSMUC1 mRNA expression was identified for twenty-six lymph nodes (15.7%), in eighteen patients (42%) who were diagnosed as having nodal micrometastasis. TNM staging for these patients was up-regulated from stages I-II(A) to stages II(B)-III. Relapse disease was found in nine patients with lymph nodes micrometastasis and three patients without nodal micrometastasis (P < 0.05).
CONCLUSIONEarly tumor relapse after radical surgery in the patients with pN(0) esophageal cancer might be correlated with nodal micrometastasis.
