Detecting multi-drug resistance of bladder cancer for the intravesical chemotherapy.
- Author:
Xin-li KANG
1
;
Zhen-hong GENG
;
Xing-xiang LU
;
Chao WEI
;
Jin-gang WANG
;
San-zhong WANG
;
Sen MA
;
Hong-xin LIU
;
Guo-ying XU
;
Hua-wei ZHANG
;
Guo-yong WANG
Author Information
- Publication Type:Journal Article
- MeSH: ATP-Binding Cassette, Sub-Family B, Member 1; analysis; Administration, Intravesical; Adult; Aged; DNA Topoisomerases, Type II; analysis; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Glutathione Transferase; analysis; Humans; Immunohistochemistry; Male; Middle Aged; Urinary Bladder Neoplasms; drug therapy; metabolism
- From: Chinese Journal of Surgery 2004;42(5):285-287
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore multi-drug resistance (MDR) of bladder cancer for the intravesical instillation.
METHODSUsing immunohistochemical staining, in 44-case human bladder cancer cells, the expressions of P-glycoprotein (P-gp), glutathione S-transferase (GST-pi) and topoisomerase (TOPO-II), were detected to find out the resistance to drugs.
RESULTSP-gp had a higher expression in 54.5% cases. GST-pi had no or a lower expression in 65.9% cases. TOPO-II had a higher expression in 29.5% but a lower expression in 65.9% cases.
CONCLUSIONDetecting the factors of MDR in bladder cancer cells could help to choose drugs for intravesical chemotherapy.
