The roles of VEGF and C-myc in occurrence, development and metastasis of gallbladder carcinoma.
- Author:
Zhimin LIU
1
;
Lili JIANG
;
Bin YANG
;
Dianying LIAO
Author Information
1. Laboratory of Surgical Department, West China Hospital, Sichuan University, Chengdu 610041.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Endothelial Growth Factors;
biosynthesis;
physiology;
Female;
Gallbladder Neoplasms;
metabolism;
pathology;
Humans;
Intercellular Signaling Peptides and Proteins;
biosynthesis;
physiology;
Lymphokines;
biosynthesis;
physiology;
Male;
Middle Aged;
Neoplasm Metastasis;
Proto-Oncogene Proteins c-myc;
biosynthesis;
physiology;
Vascular Endothelial Growth Factor A;
Vascular Endothelial Growth Factors
- From:
Journal of Biomedical Engineering
2003;20(1):68-70
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the relationship of the expression of vascular endothelial growth factor (VEGF) and C-myc with the occurrence, development and metastasis of gallbladder carcinoma, the expression levels of VEGF and C-myc in gallbladder carcinoma tissue (n = 30) and in normal gallbladder tissue (n = 20) were examined by immunochemistry. Results show that the positive rates of VEGF and C-myc in gallbladder carcinoma tissue were 80% and 63.3% respectively, and 45% and 25% respectively in normal gallbladder tissue. The positive rates of VEGF and C-myc were significantly higher in gallbladder carcinoma than in normal gallbladder tissue. The expression of VEGF and C-myc in gallbladder carcinoma related to the metastasis of gallbladder carcinoma. VEGF and C-myc play important roles in the occurrence, development and metastasis of gallbladder carcinoma.
