Study of 125I-interleukin-8 distribution in mice.
- Author:
Wo FAN
1
;
Jianhua QIAN
;
Ran ZHU
;
Yujie XU
;
Yi ZHANG
;
Benxin ZHU
Author Information
1. Department of Radiation Medicine, Suzhou University, Suzhou 215007.
- Publication Type:Journal Article
- MeSH:
Animals;
Interleukin-8;
pharmacokinetics;
Iodine Radioisotopes;
Male;
Mice;
Recombinant Proteins;
pharmacokinetics;
Tissue Distribution
- From:
Journal of Biomedical Engineering
2003;20(1):95-96
- CountryChina
- Language:Chinese
-
Abstract:
IL-8 was radiolabeled with 125I via Bolten-Hunter agent and the distribution of 125I-IL-8 in mice was determined in order to understand IL-8 behaviors in vivo. The percentage of 125I-IL-8 in blood, heart, liver, lung, kidneys, bone and spleen was obtained. The half-clearance of fast phase T1/2 alpha and slow phase T1/2 beta were 0.32 h and 8.01 h respectively. Most of 125I-IL-8 was excluded by kidneys.
