Investigation of the degradation behavior of different modified bovine pericardial in vitro.
- Author:
Qingrong WEI
1
;
Changxiu WAN
;
Hongwei YAO
;
Tianquan LI
;
Yanfang XIONG
Author Information
1. Department of Polymer Science and Engineering, Sichuan University, Chengdu 610065.
- Publication Type:Journal Article
- MeSH:
Animals;
Biodegradation, Environmental;
Bioprosthesis;
Cattle;
Cross-Linking Reagents;
chemistry;
pharmacology;
Hydroxyproline;
analysis;
In Vitro Techniques;
Materials Testing;
Pericardium;
chemistry;
drug effects;
metabolism;
Prosthesis Design;
Proteins;
analysis;
Surface Properties
- From:
Journal of Biomedical Engineering
2003;20(2):214-218
- CountryChina
- Language:Chinese
-
Abstract:
Bovine pericardium is mainly composed of collagen which has many good properties of extracellular matrix. This in vitro study was performed to quantitatively investigate and compare the degradation behavior of the bovine pericardial, which were modified with different methods. The purpose is to find out one method that presents not only the degradation regularity of material but also minimum antigenicity, so that bovine pericardium can be used as a well degradable guide tissue regeneration material. The results of the experiments showed that the bovine pericardium treated with ethanol is more appreciated than that treated with epoxy cross-linking agent or glutaraldehyde. The mensuration of protein and special amino acid may be a useful base of constructing a mathematic model for further researches on the rate of degradation of bovine pericardium.
