Expression of vascular endothelial growth factor and matrix metalloproteinase-2 correlates with the invasion and metastasis of hepatocellular carcinoma.
- Author:
Zhimin LIU
1
;
Lunan YAN
;
Tao XIANG
;
Lili JIANG
;
Bin YANG
Author Information
1. Laboratory of Surgical Department, West China Hospital of Sichuan University, Chengdu 610041.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Hepatocellular;
metabolism;
pathology;
secondary;
Endothelial Growth Factors;
biosynthesis;
Female;
Humans;
Intercellular Signaling Peptides and Proteins;
biosynthesis;
Liver Neoplasms;
metabolism;
pathology;
Lymphokines;
biosynthesis;
Male;
Matrix Metalloproteinase 2;
biosynthesis;
Middle Aged;
Neoplasm Invasiveness;
Neoplasm Metastasis;
Vascular Endothelial Growth Factor A;
Vascular Endothelial Growth Factors
- From:
Journal of Biomedical Engineering
2003;20(2):249-254
- CountryChina
- Language:English
-
Abstract:
To investigate the relationship of the expression of vascular endothelial factor (VEGF) and matrix metalloproteinase-2 (MMP-2) with the recurrence and metastasis of hepatocellular carcinoma (HCC), the expression of VEGF and MMP-2 in HCC tissue(n = 50) and in normal liver tissue(n = 30) were examined by immunochemistry. The results showed that the positive rates of VEGF and MMP-2 in HCC tissue were 86% and 60% respectively, and in normal liver tissue were 53.3% and 30% respectively. The positive rates of VEGF and MMP-2 in HCC were significantly higher than those in normal liver tissue. The positive rates of VEGF and MMP-2 in HCC with intra- or extra-hepatic metastasis were higher than those of HCC without metastasis. VEGF and MMP-2 play important roles in the invasion and metastasis of HCC.
