Study on the targeting of nanoparticles loading TK gene in mice.
- Author:
Qin HE
1
;
Ji LIU
;
Zhirong ZHANG
;
Min ZHANG
;
Li TU
Author Information
1. School of Pharmacy, Sichuan University, Chengdu 610041.
- Publication Type:Journal Article
- MeSH:
Animals;
DNA;
administration & dosage;
pharmacokinetics;
Drug Carriers;
Injections, Intravenous;
Injections, Subcutaneous;
Lactic Acid;
Mice;
Particle Size;
Plasmids;
administration & dosage;
genetics;
pharmacokinetics;
Polyglycolic Acid;
Polymers;
Thymidine Kinase;
genetics;
Tissue Distribution
- From:
Journal of Biomedical Engineering
2003;20(2):281-284
- CountryChina
- Language:Chinese
-
Abstract:
The tissue distribution of DNA-PLGA-NP was investigated by the technique of gamma scintigraphy. The results showed that 30 min after mouse caudal vein injection of 32P-DNA-PLGA-NP, the ratio of radioactivity in liver against total radioactivity is higher than 70%, which is 1.4 fold the ratio after caudal vein injection of 32P-DNA, and that 2 h after subcutaneous injection of 32P-DNA-PLGA-NP 2 h, the ratio of the radioactivity in liver against total radioactivity is also higher than 70%, reaching a 1.6 fold increase when compared with the ratio after subcutaneous injection of 32P-DNA.
