Synthesis, characterization and in vitro release of poly (succinimide-co-4-aminobutanoic acid) by acid-catalyzed polycondensation of L-aspartic acid and 4-aminobutanoic acid.
- Author:
Zhiyin LIAO
1
;
Guping TANG
Author Information
1. College of Medical Science, Zhejiang University, Hangzhou 310006.
- Publication Type:Journal Article
- MeSH:
Animals;
Aspartic Acid;
chemistry;
Female;
Hydrolysis;
Male;
Materials Testing;
Mice;
Polymers;
chemical synthesis;
chemistry;
metabolism;
toxicity;
Rabbits;
gamma-Aminobutyric Acid;
chemistry
- From:
Journal of Biomedical Engineering
2003;20(3):392-397
- CountryChina
- Language:Chinese
-
Abstract:
For the purpose of increasing the hydrophilicity of poly aspartic acid, a series of polymer of L-aspartic acid and 4-aminobutanoic acid with different ratios (mol/mol) were prepared. The copolymers were characterized by 13CNMR, DSC and x-ray. The confirmed the structures of the polymers. In-vitro tests of release at phosphate buffer saline, enzyme solution of trypsin and papain (37.0 degrees C, pH = 7.4) were carried out. The result indicated that the polymers could be degraded in some degree, and that 4-aminobutanoic acid segments accelerated the degradation rate of the polymers. Skin irritation test and systemic acute toxicity test were carried out, which showed that the polymer was a nontoxic biomedical material.
