Preparation and biological evaluation of PLA/chitosan composite materials.
- Author:
Lihua LI
1
;
Shan DING
;
Changren ZHOU
Author Information
1. Biomaterials Research Lab, Chemistry Department, Jinan University, Guangzhou 510630.
- Publication Type:Journal Article
- MeSH:
Animals;
Biocompatible Materials;
chemical synthesis;
toxicity;
Cell Adhesion;
drug effects;
physiology;
Cells, Cultured;
Chitin;
analogs & derivatives;
chemical synthesis;
toxicity;
Chitosan;
Female;
Guinea Pigs;
Lactic Acid;
chemical synthesis;
toxicity;
Male;
Materials Testing;
Polyesters;
Polymers;
chemical synthesis;
toxicity;
Rabbits
- From:
Journal of Biomedical Engineering
2003;20(3):398-400
- CountryChina
- Language:Chinese
-
Abstract:
Hypersusceptibility test, pyrogen test, cell cultivation, and toxicity examination were applied in the biological evaluation of the poly(lactic acid) (PLA)/chitosan composite materials. The results indicated that all the materials were negative, conforming to the ISO10993-1. The cell could grow well on the surface of the materials. So the PLA/chitosan composite materials have good biocompatibility and can be planted in the body as scaffolds.
