A system applying cyclic biaxial mechanical strain to cultured cells.
- Author:
Mengshi CHEN
1
;
Liang LI
;
Li DENG
;
Hua HUANG
;
Shengxiang LAI
Author Information
1. Department of Mechanical Engineering, Sichuan University, Chengdu 610065.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Culture Techniques;
instrumentation;
Equipment Design;
Finite Element Analysis;
Rats;
Stress, Mechanical
- From:
Journal of Biomedical Engineering
2003;20(3):430-433
- CountryChina
- Language:Chinese
-
Abstract:
To study the response of cultured cells to the cyclical biaxial biomechanical strain, a system was made according to the principle of Winston. The system was made of culture dish, pressure cavity and step motor. The culture dishes were made of polymethyl methacrylate and the bottom of the culture dishes were made of silicone rubber membrane. When the diameter of the silicone rubber tube and the distance between rollers and curvilinear plate changed, the pressure in the pressure cavity changed and the strain of the membrane changed from 0 to 4%. When the roll of the step motor changed, the frequency of the strain changed from 0.1 to 5 Hz.
