Regulative mechanisms of oxidative stress in kidney in diabetic nephropathy and interventional effects of Chinese herbal medicine.
- Author:
Zhi-Min MAO
;
Yan-Ru HUANG
;
Yi-Gang WAN
;
Hao-Li CHEN
;
Xi-Miao SHI
;
Xian-Jie MENG
;
Jian YAO
- Publication Type:Journal Article
- MeSH:
Animals;
Diabetic Nephropathies;
drug therapy;
metabolism;
Drugs, Chinese Herbal;
administration & dosage;
Humans;
Kidney;
drug effects;
metabolism;
Oxidative Stress;
drug effects;
Signal Transduction;
drug effects;
Treatment Outcome
- From:
China Journal of Chinese Materia Medica
2014;39(19):3707-3712
- CountryChina
- Language:Chinese
-
Abstract:
In the development of diabetic nephropathy (DN), reactive oxygen specie (ROS) over much in vivo leads to oxidative stress(OS)-related renal injuries, which are characterized by the structural and functional changes in glomerular and renal tubular cells in morphology. The regulative approaches of OS involve the several signaling pathways, in which, both p38 mitogen-activated protein kinase (MAPK) signaling pathway and adenosine monophosphate-activated protein kinase (AMPK) signaling pathway play the important roles as the target of anti-oxidants. The interventional actions of Chinese herbal compound prescriptions and the extracts of single Chinese herbal medicine (CHM) on OS in the kidney in DN include regulating the balance between ROS and antioxidants, reducing the production of AGEs, inhibiting the expression of growth factors and intervening the activity of signaling pathways.
