Development of biphasic drug-loading lipid emulsion of Salvia miltiorrhiza and its quality evaluation.
- Author:
Yin-Yan WANG
;
Xi LI
;
Xiu-Jun LAI
;
Wei LI
;
Ya-Jing YANG
;
Ting CHU
;
Sheng-Jun MAO
- Publication Type:Journal Article
- MeSH:
Chemistry, Pharmaceutical;
instrumentation;
methods;
Drugs, Chinese Herbal;
chemistry;
Emulsions;
chemistry;
Quality Control;
Salvia miltiorrhiza;
chemistry
- From:
China Journal of Chinese Materia Medica
2014;39(19):3748-3752
- CountryChina
- Language:Chinese
-
Abstract:
The feasibility of simultaneously loading both liposoluble and water-soluble components of Salvia miltiorrhiza in emulsion was discussed, in order to provide new ideas in comprehensive application of effective components in S. miltiorrhiza in terms of technology of pharmaceutics. With tanshinone II (A) and salvianolic acid B as raw materials, soybean phospholipid and poloxamer 188 as emulsifiers, and glycerin as isoosmotic regulator, the central composite design-response surface method was employed to optimize the prescription. The coarse emulsion was prepared with the high-speed shearing method and then homogenized in the high pressure homogenizer. The biphasic drug-loading intravenous emulsion was prepared to investigate its pharmaceutical properties and stability. The prepared emulsion is orange-yellow, with the average diameter of 241 nm and Zeta potential of -35.3 mV. Specifically, the drug loading capacity of tanshinone II (A) and salvianolic acid B were 0.5 g x L(-1) and 1 g x L(-1), respectively, with a good stability among long-term retention samples. According to the results, the prepared emulsion could load liposoluble tanshinone II (A) and water-soluble salvianolic acid B simultaneously, which lays a pharmaceutical foundation for giving full play to the efficacy of S. miltiorrhiza.
