Recognition of experimental animal model with kidney disease.
- Author:
Yi-gang WAN
;
Yan-ru HUANG
;
Wei SUN
;
Zhi-min MAO
;
Xi-miao SHI
;
Jian YAO
- Publication Type:Journal Article
- MeSH:
Animals;
Diabetic Nephropathies;
etiology;
Disease Models, Animal;
Humans;
Kidney Diseases;
etiology;
Medicine, Chinese Traditional;
Mice;
Streptozocin
- From:
China Journal of Chinese Materia Medica
2014;39(21):4075-4081
- CountryChina
- Language:Chinese
-
Abstract:
Animal models with kidney disease are generally divided into two types. One belongs to the models which imitate human kidney disease by the artificial operations, such as anti-glomerular basement membrane antibody nephritis, Heymann nephritis, anti-Thyl. 1 antibody nephritis, BSA nephritis and puromycin nephropathy. The other one pertains to the models which make themselves kidney disease, and appear the pathological characteristics naturally as like as human, such as HIGA mice with IgA nephropathy and NZB/WF1 and MRL/1pr mice with lupus nephritis. In addition,the transgenic animal models with kidney disease can also be established by the modern molecular biologic techniques including gene knockout and siRNA transfection. As for the studies related with kidney disease in pharmacodynamics and pharmacology of Chinese herbal medicine (CHM), it is important to understand deeply the features of each animal model with kidney disease, and select accurately the proper models according to the different experimental objectives, and then, build the special models provided with the combination of disease with syndrome in traditional Chinese medicine (TCM). Therefore,it is the developmental direction for the further study to establish animal models with kidney disease, which should possess the characteristics of syndrome in TCM.
