Qualitative analysis of a sulfur-fumigated Chinese herbal medicine by comprehensive two-dimensional gas chromatography and high-resolution time of flight mass spectrometry using colorized fuzzy difference data processing.
- Author:
Hao CAI
1
;
Gang CAO
2
;
Hong-Yan ZHANG
3
Author Information
- Publication Type:Journal Article
- Keywords: Radix Angelicae Sinensis; colorized fuzzy difference; comprehensive two-dimensional gas chromatography and high-resolution time-of-flight mass spectrometry; volatile components
- MeSH: Color; Drugs, Chinese Herbal; analysis; Fumigation; Fuzzy Logic; Gas Chromatography-Mass Spectrometry; methods; Oils, Volatile; analysis; Reference Standards; Sulfur; analysis; Volatile Organic Compounds; analysis
- From: Chinese journal of integrative medicine 2017;23(4):261-269
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the chemical transformation of volatile compounds in sulfur-fumigated Radix Angelicae Sinensis.
METHODSA comprehensive two-dimensional gas chromatography (GC×GC) and high-resolution time-of-flight mass spectrometry (HR-TOF/MS) with colorized fuzzy difference (CFD) method was used to investigate the effect of sulfur-fumigation on the volatile components from Radix Angelicae Sinensis.
RESULTSTwenty-five compounds that were found in sun-dried samples disappeared in sulfur-fumigated samples. Seventeen volatile components including two sulfur-containing compounds were newly generated for the first time in volatile oils of sulfur-fumigated Radix Angelicae Sinensis.
CONCLUSIONThe strategy can be successfully applied to rapidly and holistically discriminate sun-dried and sulfur-fumigated Radix Angelicae Sinensis. GC×GC-HR-TOF/MS based CFD is a powerful and feasible approach for the global quality evaluation of Radix Angelicae Sinensis as well as other herbal medicines.
