The expressional alterations of CSF-1R after ischemic injury of cerebral cortex.
- Author:
Dong Hui YU
1
;
Shuang LIU
;
Zeng-Min TIAN
;
Shu-Hong LIU
;
Xue-Ming GE
;
Chang-Man ZHOU
;
Ya-Qi WANG
;
Ming FAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Ischemia; pathology; physiopathology; Cerebral Cortex; blood supply; Female; Macrophage Colony-Stimulating Factor; physiology; Male; Mice; Mice, Inbred BALB C; Neurons; metabolism; Random Allocation; Receptor, Macrophage Colony-Stimulating Factor; genetics; metabolism; physiology; Reperfusion Injury; metabolism; physiopathology
- From: Chinese Journal of Applied Physiology 2008;24(1):6-9
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo observe the expressional alterations of colony stimulating factor-1 receptor (CSF-1R) after ischemic injury of cerebral cortex, and study the function of colony stimulating factor-1 (CSF-1)/CSF-1R signal during the process of ischemic injury and repair of central nervous system (CNS).
METHODSWe examined the distribution and expression of CSF-1R in normal brain tissues and ischemic brain tissues by immunohistology and Western blot analysis.
RESULTSThe expression of CSF-1R in neurons could be up-regulated by ischemic injury in CNS.
CONCLUSIONCSF-1/CSF-1R might take part in the process of ischemic injury and repair.
