Correlation between the refractory periods and threshold potentials and the spike programming in cortical neurons.
- Author:
Na CHEN
1
;
Ying-Liang WU
;
Jin-Hui WANG
Author Information
- Publication Type:Journal Article
- MeSH: Action Potentials; physiology; Animals; Animals, Newborn; Cerebral Cortex; cytology; physiology; Differential Threshold; physiology; Interneurons; physiology; Neurons; physiology; Patch-Clamp Techniques; Pyramidal Cells; physiology; Rats; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; physiology; Synaptic Transmission; physiology
- From: Chinese Journal of Applied Physiology 2008;24(1):14-17
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the intrinsic mechanisms underlying spike programming at pyramidal neurons and interneurons in layer II/III of sensorimotor cortex.
METHODSElectrical signals at the cortical neurons were recorded in current clamp model with multi-clamp700B Amplifiers. Signals were inputted into pClamp and Origin for data acquisition and analyses.
RESULTSCompared to pyramidal neurons, interneurons express the higher capacity of spikes and the more stability of spike programming, which are mechanistically caused by lower threshold potentials and shorter refractory periods.
CONCLUSIONThe refractory periods and threshold potentials directly influence the programming of sequential spikes.
