Anti-hypoxia protective role of the effective component extracted from angelia injection.
- Author:
Ming-Ming LI
1
;
Li-Ying WU
;
Tong ZHAO
;
Ai-Lin DU
;
Lei XIONG
;
Hua ZHAO
;
Xin HUANG
;
Ling-Ling ZHU
;
Ming FAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Hypoxia; Cell Line; Cell Survival; drug effects; Drugs, Chinese Herbal; pharmacology; Furans; pharmacology; Glycosides; pharmacology; Hypoxia; drug therapy; Male; Mice
- From: Chinese Journal of Applied Physiology 2008;24(2):147-150
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate anti-hypoxia protective roles of the effective component extracted from angelia injection using hypoxia injury model in mice and ECV304 cells separately.
METHODSThe survival time of mice was observed separately under normobaric and hypobaric hypoxia. The activity of ECV304 cells was tested by MTT assay, and the mortality rate was examined by Trypan blue exclusion assay to evaluate the pharmacodynamic effects.
RESULTSAfter exposed to hypoxia the survival time of mice was increased in medicine groups,compared with the control groups (P < 0.05). The cell survival rate was decreased and the cell mortality rate was increased after cells were exposed to hypoxia,while the cell survival rate was significantly increased (P < 0.01), and the cell mortality rate was significantly decreased (P < 0.1) in the medicine groups compared with the control groups.
CONCLUSIONThe effective component extracted from angelia injection can protect against the injury induced by hypoxia.
