Inulicin inhibits activation and expression of vascular remodeling enzymes induced by de-endothelium.
- Author:
Juan-Juan LI
1
;
Jin-Kun WEN
;
Mei HAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Endothelium, Vascular; drug effects; enzymology; metabolism; Hyperplasia; prevention & control; Male; Matrix Metalloproteinase 2; metabolism; Neointima; prevention & control; Rats; Rats, Sprague-Dawley; Sesquiterpenes; pharmacology; Tissue Inhibitor of Metalloproteinase-2; metabolism
- From: Chinese Journal of Applied Physiology 2008;24(2):156-160
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo observe the effects of inulicin on the neointimal hyperplasia and expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) after balloon injury in rat aorta.
METHODSThe intimal hyperplasia model was replicated by balloon injury. The histological changes in vascular wall were observed by HE staining. MMP-2 activation was tested by gelatin zymogram analysis; MMP-2 and TIMP-2 expression was detected by Western blot and immunohistochemistry analysis.
RESULTSNeointimal hyperplasia induced by balloon injury was significantly inhibited by inulicin. The proteolytic activity and the expression of MMP-2 and ratio of MMP-2 and TIMP-2 were also returned to control level by inulicin after balloon injury.
CONCLUSIONInulicin inhibits hyperplasia of neointima by modulating the balance of MMP-2 and TIMP-2.
