The changes of neurotransmitter content in spinal cord after exercise-induced central fatigue.
- Author:
Chuan-Xiang XU
1
;
Hong-Tao LIU
;
Jing WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Fatigue; metabolism; Male; Motor Neurons; metabolism; Neurotransmitter Agents; metabolism; Physical Conditioning, Animal; Rats; Rats, Wistar; Spinal Cord; metabolism; Synaptic Transmission
- From: Chinese Journal of Applied Physiology 2008;24(2):225-228
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the changes of neurotransmitter concentration in spinal cord after exercise-induced central fatigue and study the mechanism of central fatigue at spinal level.
METHODSEstablish exercise-induced central fatigue model according to Bedford incremental loading training. The rats were divided into three groups, control group (C), immediately after training group (IT), rest 3 hours after training group (RT). Then using high performance liquid chromatography (HPLC) to detect the concentration of neurotransmitter in spinal cord.
RESULTSAmino acid neurotransmitters in spinal cord increased in IT group: Glu, GABA increased significantly (P < 0.05), Gly also increased but have no statistic difference; while in RT group, amino acid neurotransmitters got back to normal. However monoamine neurotransmitters NE, 5-HT tended to decrease in IT group. In RT group 5-HT decreased dramatically (P < 0.05).
CONCLUSIONExercise-induced fatigue changed the concentration of neurotransmitter in spinal cord.The results suggested that neurotransmitter in spinal cord might have relationship with exercise-induced fatigue, especially 5-HT might have more important effect on recovery of fatigue.
