Efficacy and Safety of Bortezomib in Multiple Myeloma Patients with Hepatitis B: A Multicenter Retrospective Study.
- Author:
Jin LU
;
Wen-Ming CHEN
;
Chuan-Ying GENG
;
Brian Gm DURIE
;
Xiao-Jun HUANG
1
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Antiviral Agents; therapeutic use; Bortezomib; therapeutic use; DNA, Viral; drug effects; genetics; Female; Hepatitis B; drug therapy; virology; Hepatitis B virus; drug effects; pathogenicity; Humans; Male; Middle Aged; Multiple Myeloma; drug therapy; virology; Retrospective Studies; Viral Load
- From: Chinese Medical Journal 2016;129(3):274-278
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDThe efficacy and safety evidence of bortezomib in multiple myeloma (MM) patients with hepatitis B is vacant. This study aimed to investigate the efficacy and safety of bortezomib in MM patients with hepatitis B in China.
METHODSFrom 2006 to 2011, 739 newly diagnosed MM patients were screened for serum hepatitis B virus (HBV) biomarkers. HBV-infected patients were followed for HBV reactivation by monitoring of serum alanine transaminase (ALT) and HBV DNA load. The pattern of HBV reactivation in relation to bortezomib was evaluated. Seven hundred thirty-nine MM patients were included in this study.
RESULTSThe prevalence of MM patients infected with HBV was 3.4% (n = 25), of which 17 cases were treated with bortezomib. Bortezomib had no significant influence on liver function (ALT before and after treatment: 36.69 ± 8.90 U/L vs. 11.31 ± 2.74 U/L, P = 0.19) and HBV DNA of MM patients with HBV (detectable HBV DNA percentage: 5.9% vs. 11.8%, P = 0.12).
CONCLUSIONSBortezomib can be used safely and effectively in MM patients with hepatitis B. HBV prophylaxis and surveillance are recommended during the MM treatment.
