Smart therapeutics based on synthetic gene circuits.

Author: Shuguang PENG ¹ ; Zhen XIE ¹
Author Information

1. MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, Department of Automation, Tsinghua National Laboratory for Information Science and Technology, Tsinghua University, Beijing 100084, China.
Publication Type:Journal Article
Keywords: bacterial therapy; cell therapy; gene circuits; gene therapy; synthetic biology
From: Chinese Journal of Biotechnology 2017;33(3):456-466
CountryChina
Language:Chinese
Abstract: Synthetic biology has an important impact on biology research since its birth. Applying the thought and methods that reference from electrical engineering, synthetic biology uncovers many regulatory mechanisms of life systems, transforms and expands a series of biological components. Therefore, it brings a wide range of biomedical applications, including providing new ideas for disease diagnosis and treatment. This review describes the latest advances in the field of disease diagnosis and therapy based on mammalian cell or bacterial synthetic gene circuits, and provides new ideas for future smart therapy design.