Progress in c-di-GMP inhibitors.

Author: Xuwen XIANG ¹ ; Xingyu LIU ¹ ; Hui TAO ¹ ; Zining CUI ¹ ; Lianhui ZHANG ¹
Author Information

1. State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangzhou 510642, Guangdong, China.
Publication Type:Journal Article
Keywords: c-di-GMP; diguanylatecyclases; inhibitors; phosphodiesterases; receptors
From: Chinese Journal of Biotechnology 2017;33(9):1466-1477
CountryChina
Language:Chinese
Abstract: The cyclic dinucleotide c-di-GMP is known as an important second messenger in bacteria, which controls various important cellular processes, such as cell differentiation, biofilm formation and virulence factors production. It is extremely vital for the development of new antibacterial agents by virtue of blocking c-di-GMP signal conduction. Current research indicates that there are three potential targets for discovering new antibacterial agents based on c-di-GMP regulated signal pathway, which are c-di-GMP synthases, c-di-GMP degrading enzymes and c-di-GMP receptors. Herein, we review small molecules that have been developed to inhibit c-di-GMP related enzymes and indicate perspectives of c-di-GMP inhibitors.