Manipulation of cofactor balance in microorganisms.

Author: Xiulai CHEN ¹ ; Jia LIU ¹ ; Qiuling LUO ¹ ; Liming LIU ¹
Author Information

1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China.
Publication Type:Journal Article
Keywords: NADH; cofactor; manipulation strategy; metabolic engineering; synthetic biology
From: Chinese Journal of Biotechnology 2017;33(1):16-26
CountryChina
Language:Chinese
Abstract: Cofactor balance plays an important role in producing enzymes, pharmaceuticals and chemicals. To meet the demand of industrial production, microbes should maintain a maximal carbon flux towards target metabolites without fluctuations in cofactor. We reviewed the physiological function of cofactor and discussed detailed strategies to manipulate cofactor balance through biochemical engineering and metabolic engineering. Furthermore, we indicated future research needs to further regulate cofactor balance.