Advances in biosynthesis of 2-phenylethanol by yeasts.

Author: Xianrui CHEN ¹ ; Zhaoyue WANG ¹ ; Xiuping HE ¹
Author Information

1. CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Publication Type:Journal Article
Keywords: 2-phenylethanol; gene; metabolic pathway; regulation; yeast
MeSH: Biotransformation; Industrial Microbiology; Metabolic Networks and Pathways; Phenylethyl Alcohol; metabolism; Saccharomyces cerevisiae; metabolism
From: Chinese Journal of Biotechnology 2016;32(9):1151-1163
CountryChina
Language:Chinese
Abstract: 2-Phenylethanol (2-PE) is an aromatic alcohol with a pleasant rose-like fragrance. It has been widely used in food, cosmetic, and pharmaceutical industry. Most of 2-PE is produced by chemical synthesis, but the use of chemically synthesized product is restricted in some fields. 2-PE from plant extraction is natural but its production is very low. Microbial biotransformation is a promising process to produce natural 2-PE. In this paper, we review recent research progress in the synthetic metabolic pathways and regulatory processes of 2-PE in yeast, and strategies for improving 2-PE production. Moreover, we discuss the limitation of current progress and future research directions.