Study on Receptor-Mediated Catecholamine Activation of Brain Cortical Na-K-ATPase.
- Author:
Jin Mik KIM
1
;
Young Woo LEE
Author Information
1. Department of Neurosurgery, School of Medicine, Pusan National University, Korea.
- Publication Type:Original Article
- Keywords:
Na-K-ATPase;
Catechol analogues;
Adrenergic agonists;
Catecholic receptors;
EDTA
- MeSH:
Adrenergic Agonists;
Adrenergic beta-Agonists;
Animals;
Brain*;
Catecholamines;
Dopamine;
Edetic Acid;
Isoproterenol;
Phenoxybenzamine;
Phentolamine;
Propranolol;
Rats;
Structure-Activity Relationship
- From:Journal of Korean Neurosurgical Society
1985;14(2):281-292
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In order to examine the properties of catecholic receptor-mediated activation of Na-K-ATPase reaction, author have studied. 1) the structure-activity relationships of various catechol analogues as stimulants of rat cortical Na-K-ATPase. 2) the stereospecificity of alpha and beta-adrenergic agonists on their activation of enzyme system and 3) the relationship of the receptive sites to the enzyme Na-K-ATPase and the effect of EDTA. The observed results were as follows: 1) Noradrenalin, dopamine and isoproterenol stimulated the Na-K-ATPase activity in rat cortical nomogenate. 2) The Na-K-ATPase activation elicited by catecholamines could not be antagonized by beta-receptor blocker, phentolamine and alpha-receptor blocker, propranolol decreased the increase in activity evoked by catecholamine, but it could not inhibit completely. 3) alpha-receptor blocker, phenoxybenzamine inhibited the noradrenalin activation on Na-K-ATPase, and decreased the effect of EDTA on the Na-K-ATPase activity.
