17beta-estradiol stimulates proliferation of spermatogonia in experimental cryptorchid mice.
- Author:
En-Zhong LI
1
;
De-Xue LI
;
Shi-Qing ZHANG
;
Chang-Yong WANG
;
Xue-Ming ZHANG
;
Jing-Yan LU
;
Cui-Mi DUAN
;
Xiang-Zhong YANG
;
Li-Xin FENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Division; drug effects; Cryptorchidism; physiopathology; Disease Models, Animal; Estradiol; blood; pharmacology; Follicle Stimulating Hormone; blood; Luteinizing Hormone; blood; Male; Mice; Spermatogonia; cytology; drug effects; pathology; Testosterone; blood
- From: Asian Journal of Andrology 2007;9(5):659-667
- CountryChina
- Language:English
-
Abstract:
AIMTo investigate whether estrogen stimulates the proliferation of spermatogonia or induces spermatogenesis in cryptorchid mice.
METHODSMice were surgically rendered cryptorchid, then treated with different doses of 17beta-estradiol (E2) s.c. once a day. Mice were killed at sexual maturity (45 days of age), and histological analysis and immunofluorescence were performed. Serum follicle stimulating hormone (FSH), estradiol, testosterone and luteinizing hormone (LH) were measured.
RESULTSLow doses of E2 had no notable effect on spermatogonia, but at higher doses, E2 stimulated the proliferation of spermatogonia.
CONCLUSIONE2 has a dose-related mitogenic effect on spermatogonia.
