Comparisons of voided urine cytology, nuclear matrix protein-22 and bladder tumor associated antigen tests for bladder cancer of geriatric male patients in Taiwan, China.
- Author:
Ke-Hung TSUI
1
;
Shao-Ming CHEN
;
Ta-Ming WANG
;
Horng-Heng JUANG
;
Chien-Lun CHEN
;
Guang-Huan SUN
;
Phei-Lang CHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Humans; Male; Nuclear Proteins; urine; Taiwan; Urinary Bladder Neoplasms; diagnosis; urine; Urine; cytology
- From: Asian Journal of Andrology 2007;9(5):711-715
- CountryChina
- Language:English
-
Abstract:
AIMTo compare the results of bladder tumor associated antigen (BTA TRAK), nuclear matrix protein 22 (NMP 22) and voided urine cytology (VUC) in detecting bladder cancer.
METHODSA total of 135 elderly male and 50 healthy volunteers enrolled in this study were classified into three groups: (i) 93 patients with bladder cancer; (ii) 42 patients with urinary benign conditions; and (iii) 50 healthy volunteers. BTA TRAK and NMP 22 kits were used to detect bladder cancer. Voided urine cytology was used to compare the sensitivity and specificity of the screening tests.
RESULTSThe sensitivity and specificity of cytology, BTA TRAK and NMP 22 were 24% and 97%, 51% and 73%, 78% and 73%, respectively. The level of NMP 22 increased with tumor grading. The BTA TRAK kit has the lowest sensitivity among the screening tests. The NMP 22 with the best sensitivity can be an adjunct to cytology for evaluating bladder cancer.
CONCLUSIONThe NMP 22 test has a better correlation with the grading of the bladder cancer than BTA TRAK. As cytology units are typically not available in hospitals or in outpatient clinics, NMP 22 might be a promising tool for screening bladder cancer.
