Alpha-synuclein interacted proteins: the relevance with the pathogenesis of Parkinson's disease.
- Author:
Fei XU
1
;
Jian-hong LUO
;
Jing-hua JIN
Author Information
1. Institute of Neuroscience, College of Medicine, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Carrier Proteins;
metabolism;
HSP70 Heat-Shock Proteins;
metabolism;
Humans;
Lewy Bodies;
metabolism;
pathology;
Nerve Tissue Proteins;
metabolism;
Parkinson Disease;
etiology;
metabolism;
Protein Interaction Domains and Motifs;
Substantia Nigra;
pathology;
alpha-Synuclein;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2008;37(5):524-530
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD) is characterized pathologically by the relatively preferential loss of dopaminergic neurons with resultant depletion of striatal dopamine and presence of Lewy bodies mainly composed by alpha-synuclein (alpha-SYN) in the remaining neurons in the substantia nigra. A lot of evidence suggests that the aggregation of alpha-SYN play an essential role in the pathogenesis of PD and formation of Lewy body. Increasing findings have implicated that some proteins, including parkin, synphilin-1,14-3-3, agrin and tau, interact with alpha-SYN and are involved in the abnormal aggregation of alpha-SYN.
