T lymphocyte subgroups and serum levels of trace elements in patients with diarrhea type of irritable bowel syndrome.
- Author:
Hang-bin JIN
1
;
Zhu-ying GU
;
Hong-wen ZHAO
;
Qun-yan WANG
;
Wei WU
;
You-ming LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; CD4-CD8 Ratio; Case-Control Studies; Copper; blood; Diarrhea; etiology; Female; Humans; Iron; blood; Irritable Bowel Syndrome; blood; complications; immunology; Male; Middle Aged; Selenium; blood; T-Lymphocyte Subsets; immunology; Trace Elements; blood; Zinc; blood
- From: Journal of Zhejiang University. Medical sciences 2008;37(6):634-637
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the T lymphocyte subgroups and the levels of serum zinc (Zn), selenium (Se), iron (Fe), copper (Cu) in patients with diarrhea type of irritable bowel syndrome (D-IBS).
METHODSA total of 30 D-IBS patients and 30 control subjects were enrolled in this study, and their peripheral blood samples were collected. The percentage of peripheral CD3, CD4, CD8 T lymphocytes were analyzed by flow cytometry, and the ratio of CD4/CD8 was calculated. Serum Zn, Fe and Cu levels were determined by atomic absorption spectrometry(AAS), and the Se level by atomic fluorometry.
RESULTCompared with control group,the percentage of CD4 T lymphocyte and the ratio of CD4/CD8 in D-IBS group were significantly lower (P<0.01). However, there was no significant difference in serum Zn, Se, Fe, Cu levels between two groups (P>0.05).
CONCLUSIONThe declines of peripheral blood CD4 T lymphocytes and the ratio of CD4/CD8 may suggest a cellular immune abnormality in D-IBS patients. There was no significant difference in trace elements levels between the two groups.
