Clinical analysis of 10 cases of olfactory neuroblastoma.

Author: Hua-Lin WANG ¹ ; Guo-Kang FAN ; Zhi-Hong LIN
Author Information

1. Department of Otolaryngology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Publication Type:Journal Article
MeSH: Adult; Aged; Combined Modality Therapy; Esthesioneuroblastoma, Olfactory; diagnosis; pathology; radiotherapy; surgery; Female; Humans; Male; Middle Aged; Nasal Cavity; Nose Neoplasms; diagnosis; pathology; radiotherapy; surgery; Retrospective Studies
From: Journal of Zhejiang University. Medical sciences 2009;38(1):103-106
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo review the diagnosis, treatment and prognosis of olfactory neuroblastoma.
METHODSClinical data were retrospectively reviewed in 10 cases of olfactory neuroblastoma admitted from 1998 to 2002, including data of transmission electron microscopic (TEM) observation in 4 cases. According to Kadish's classification, 2 cases were in stage A, 4 in stage B and 4 in stage C. Three patients were treated with surgery alone, 7 with combined surgery and radiation.
RESULTAmong 10 cases, the overall 5-year survival rate was 60 %(6/10); 3 patients died from local recurrence, 1 lost follow-up. TEM demonstrated granules in the cytoplasm of 3 patients.
CONCLUSIONThe combined surgery and radiation can achieve excellent local control. Transmission electron microscope is important for its diagnosis.