Drug permeability through buccal mucosa.
- Author:
Xu-chun FU
1
;
Xiao-jiao PAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Benzoic Acid; pharmacokinetics; Caffeine; pharmacokinetics; Hydrocortisone; pharmacokinetics; In Vitro Techniques; Mouth Mucosa; metabolism; Permeability; drug effects; Swine
- From: Journal of Zhejiang University. Medical sciences 2009;38(2):181-185
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of physicochemical properties of drug on its permeability through buccal mucosa.
METHODSBenzoic acid, caffeine and hydrocortisone were selected as model drugs and their permeability coefficients through isolated porcine buccal mucosa were determined.
RESULTThe permeability coefficients of benzoic acid, caffeine and hydrocortisone through isolated porcine buccal mucosa were (1.01 x 10(-4)+/-1.64 x 10(-5))cm.s(-1)ì(2.75 x 10(-5)+/-1.79 x 10(-6))cm.s(-1) and (2.49 x 10(-5)+/-6.32 x 10(-6))cm.s(-1), which were 14,989 and 389 times as those through human skin, respectively.
CONCLUSIONThe permeability of drugs through buccal mucosa seems to be much better than that through human skin.
