Function of TM4SF-integrins complexes in regulating cancer metastasis.
- Author:
Lin-jing ZHU
1
;
Chong LAI
Author Information
1. Department of Pathology, College of Medicine, Zhejiang University, Hangzhou 310058, China. zhulingjing@gmail.com
- Publication Type:Journal Article
- MeSH:
Cell Adhesion;
Humans;
Integrins;
chemistry;
metabolism;
physiology;
Membrane Proteins;
chemistry;
metabolism;
physiology;
Neoplasm Metastasis;
Neoplasms;
metabolism;
pathology;
Tetraspanins
- From:
Journal of Zhejiang University. Medical sciences
2009;38(2):208-214
- CountryChina
- Language:Chinese
-
Abstract:
Distant metastasis is the main cause of cancer death. Tetraspanins (transmembrane 4 superfamily, TM4SF) is capable of forming transmembrane complexes with integrin family participating in cell adhesion, migration and tumor metastasis. This review elucidates the structure of tetraspanins and its function in regulating metastasis as form of multimolecular transmembrane complexes with integrin.
