Determination of Th1/Th2 cytokines and chemokines in patients with allergic diseases and its significance.
- Author:
Rui HAN
1
;
Ai-hua LIN
;
Ke-jian ZHU
;
Hao CHENG
;
Shan-dong WU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Chemokines; blood; Child; Child, Preschool; Cytokines; blood; Female; Humans; Hypersensitivity; blood; immunology; Interferon-gamma; blood; Interleukin-13; blood; Interleukin-4; blood; Leukotriene B4; blood; Male; Middle Aged; Th1 Cells; immunology; Th2 Cells; immunology; Young Adult
- From: Journal of Zhejiang University. Medical sciences 2009;38(4):352-356
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine Th1/Th2 cytokines and chemokines in patients with allergic diseases and its clinic significance.
METHODSSerum levels of IFN-gamma, IL-4, IL-5, IL-13, Eotaxin, RANTES and LTB4 were determined from peripheral blood of 64 allergic patients and 21 healthy controls with ELISA.
RESULTSIL-4, IL-5, IL-13 and Eotaxin, LTB4 were increased significantly in serum of allergic patients compared with those of controls (P<0.05). There were no significant differences in serum levels of IFN-gamma and RANTES between patients and controls (P>0.05). Serum levels of IL-4, IL-5, IL-13 and LTB4 were correlated with each other (P<0.01). Eotaxin, RANTES and IFN-gamma levels were also significantly correlated with each other (P<0.05). LTB4 was correlated with Eotaxin as well (P<0.01).
CONCLUSIONA wide range of cytokines and chemokines is involved in allergic diseases,which may play their roles in a complex interactive manner.
